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29,435 results

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Total Synthesis of Pentaketide Ansamycin Microansamycin H.
Sittihan S, Ruchirawat S. Sittihan S, et al. Org Lett. 2022 Jun 24;24(24):4470-4473. doi: 10.1021/acs.orglett.2c01760. Epub 2022 Jun 14. Org Lett. 2022. PMID: 35700387
Herein, we report the first total synthesis of pentaketide ansamycin microansamycin H. Key to our success was the endo-selective epoxide-opening O-alkylation to construct the elusive seven-membered benzoxepane core. ...
Herein, we report the first total synthesis of pentaketide ansamycin microansamycin H. Key to our success was the endo-selective epox …
Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy.
Porter JR, Ge J, Lee J, Normant E, West K. Porter JR, et al. Curr Top Med Chem. 2009;9(15):1386-418. doi: 10.2174/156802609789895719. Curr Top Med Chem. 2009. PMID: 19860734 Review.
The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer researchers for nearly four decades. ...Since a vast amount of scientific literature exists regarding the ansamycin field and Hsp90 inhibition …
The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer researche …
Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin.
Xu S, Arimoto H. Xu S, et al. J Antibiot (Tokyo). 2016 Apr;69(4):203-12. doi: 10.1038/ja.2016.5. Epub 2016 Feb 10. J Antibiot (Tokyo). 2016. PMID: 26860467 Review.
Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. ...
Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all …
Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G.
Wei F, Wang Z, Lu C, Li Y, Zhu J, Wang H, Shen Y. Wei F, et al. Org Lett. 2019 Oct 4;21(19):7818-7822. doi: 10.1021/acs.orglett.9b02804. Epub 2019 Sep 16. Org Lett. 2019. PMID: 31525059
Ansamycins are a class of macrolactams with diverse bioactivities, characterized by the unique 3-amino-5-hydroxybenzoic acid moiety. In this study, the ansamycin gene cluster aas in Streptomyces sp. S35 was activated by the constitutive coexpression of two pathway-s …
Ansamycins are a class of macrolactams with diverse bioactivities, characterized by the unique 3-amino-5-hydroxybenzoic acid moiety. …
Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.
Nong XH, Tu ZC, Qi SH. Nong XH, et al. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127168. doi: 10.1016/j.bmcl.2020.127168. Epub 2020 Apr 3. Bioorg Med Chem Lett. 2020. PMID: 32273216
Fourteen ansamycin derivatives including seven new herbimycins G-L (1-6) and divergolide O (7), and seven known analogues were isolated from a culture broth of the marine-derived Streptomyces sp. ...Compounds 1-5 and 7 featured an additional eight-membered O-heterocycle th …
Fourteen ansamycin derivatives including seven new herbimycins G-L (1-6) and divergolide O (7), and seven known analogues were isolat …
Systematic review of drug-drug interactions between rifamycins and anticoagulant and antiplatelet agents and considerations for management.
MacDougall C, Canonica T, Keh C, P Phan BA, Louie J. MacDougall C, et al. Pharmacotherapy. 2022 Apr;42(4):343-361. doi: 10.1002/phar.2672. Epub 2022 Feb 28. Pharmacotherapy. 2022. PMID: 35152432 Review.
Rifamycins (rifampin, rifabutin, and rifapentine) play an essential role in the treatment of mycobacterial and some nonmycobacterial infections. ...Our review suggests most combinations of AC/AP agents and rifampin are problematic. Further studies are required to determine …
Rifamycins (rifampin, rifabutin, and rifapentine) play an essential role in the treatment of mycobacterial and some nonmycobacterial …
Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423.
Guo ZK, Wang YC, Tan YZ, Abulaizi A, Xiong ZJ, Zhang SQ, Yang Y, Yang Y, Shi J. Guo ZK, et al. Org Lett. 2023 Jun 9;25(22):4203-4207. doi: 10.1021/acs.orglett.3c01539. Epub 2023 May 26. Org Lett. 2023. PMID: 37232514
The nagimycins have a unique butenolide moiety rarely found in ansamycin antibiotics. Genome analysis revealed the putative biosynthetic gene cluster for nagimycins, and a likely biosynthetic pathway was proposed. ...
The nagimycins have a unique butenolide moiety rarely found in ansamycin antibiotics. Genome analysis revealed the putative biosynthe …
The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.
Floss HG, Yu TW, Arakawa K. Floss HG, et al. J Antibiot (Tokyo). 2011 Jan;64(1):35-44. doi: 10.1038/ja.2010.139. Epub 2010 Nov 17. J Antibiot (Tokyo). 2011. PMID: 21081954 Review.
The aminoshikimate pathway of formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of ansamycin and other antibiotics is reviewed. In this biosynthesis, genes for kanosamine formation have been recruited from other genomes, to provide a nitrogenous precursor. . …
The aminoshikimate pathway of formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of ansamycin and other antibiotics is …
Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity.
Skrzypczak N, Pyta K, Bohusz W, Leśniewska A, Gdaniec M, Ruszkowski P, Schilf W, Bartl F, Przybylski P. Skrzypczak N, et al. J Org Chem. 2023 Jul 7;88(13):9469-9474. doi: 10.1021/acs.joc.3c00493. Epub 2023 Jun 5. J Org Chem. 2023. PMID: 37276434 Free PMC article.
The metal-free cascade transformation of geldanamycin benzoquinone core is proposed at relatively mild conditions. This approach yields new benzoxazole ansamycin antibiotics and enables their functionalization in an atom-economic manner, irrespective of the type of amine u …
The metal-free cascade transformation of geldanamycin benzoquinone core is proposed at relatively mild conditions. This approach yields new …
New ansamycin derivatives generated by simultaneous mutasynthesis.
Song YN, Jiao RH, Zhang WJ, Zhao GY, Dou H, Jiang R, Zhang AH, Hou YY, Bi SF, Ge HM, Tan RX. Song YN, et al. Org Lett. 2015 Feb 6;17(3):556-9. doi: 10.1021/ol5035639. Epub 2015 Jan 22. Org Lett. 2015. PMID: 25611625
The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype convertibility is adopted to establish for the first time the simultaneous mutasynthesis of both types of C17-benzene ansamycins (C1 …
The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype …
29,435 results
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